1-PIPERIDINECARBOXYLIC ACID, 3-AMINO-, 1,1-DIMETHYLETHYL ESTER
1-BOC-3-AMINOPIPERIDINE
CAS: 144243-24-3;184637-48-7
Molecular Formula: C10H20N2O2
1-PIPERIDINECARBOXYLIC ACID, 3-AMINO-, 1,1-DIMETHYLETHYL ESTER - Names and Identifiers
1-PIPERIDINECARBOXYLIC ACID, 3-AMINO-, 1,1-DIMETHYLETHYL ESTER - Physico-chemical Properties
| Molecular Formula | C10H20N2O2 |
| Molar Mass | 200.28 |
| Melting Point | 181-182℃ |
| Boling Point | 277.3°C at 760 mmHg |
| Flash Point | 121.5°C |
| Vapor Presure | 0.00456mmHg at 25°C |
| Appearance | White solid |
| Color | Colorless to yellow |
| Storage Condition | Room Temprature |
1-PIPERIDINECARBOXYLIC ACID, 3-AMINO-, 1,1-DIMETHYLETHYL ESTER - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| HS Code | 29333990 |
1-PIPERIDINECARBOXYLIC ACID, 3-AMINO-, 1,1-DIMETHYLETHYL ESTER - Introduction
1-BOC-3-AMINOPIPERIDINE (also known as tert-butoxycarbonyl-piperazin-3-amine) is an organic compound with the chemical formula C12H21N3O2.
Its properties are as follows:
-Appearance: It is a white crystalline solid.
-Melting point: About 80-85 degrees Celsius.
-Solubility: It can be dissolved in water and common organic solvents.
The main use of 1-BOC-3-AMINOPIPERIDINE is as a pharmaceutical intermediate, especially in the synthesis of anti-epileptic drugs and other applications. It can also be used to synthesize pesticides and dyes.
The preparation of 1-BOC-3-AMINOPIPERIDINE can be carried out by the following steps:
1. First, mix piperidine and tetramethylcarbonic anhydride together, and add an appropriate amount of solvent, such as dimethylformamide.
2. Then, at a low temperature, slowly add ammonia solution Dropwise to keep the reaction temperature at about 0-5 degrees Celsius.
3. After the reaction is completed, the reaction mixture is usually neutralized with acid and base, and then extracted and washed with an appropriate solvent.
4. Finally, the pure product can be obtained by filtration, crystallization and drying.
Regarding safety information, 1-BOC-3-AMINOPIPERIDINE is generally relatively safe under reasonable operating conditions. However, it is still a chemical substance, so the following points need to be paid attention:
-During operation, avoid contact with skin and eyes. If exposed, immediately flush the affected area with plenty of water and seek medical help.
-When operating, maintain good ventilation conditions and avoid inhaling volatile gases or dust.
-In use and storage, should follow the correct laboratory safety procedures and personal protective measures.
Its properties are as follows:
-Appearance: It is a white crystalline solid.
-Melting point: About 80-85 degrees Celsius.
-Solubility: It can be dissolved in water and common organic solvents.
The main use of 1-BOC-3-AMINOPIPERIDINE is as a pharmaceutical intermediate, especially in the synthesis of anti-epileptic drugs and other applications. It can also be used to synthesize pesticides and dyes.
The preparation of 1-BOC-3-AMINOPIPERIDINE can be carried out by the following steps:
1. First, mix piperidine and tetramethylcarbonic anhydride together, and add an appropriate amount of solvent, such as dimethylformamide.
2. Then, at a low temperature, slowly add ammonia solution Dropwise to keep the reaction temperature at about 0-5 degrees Celsius.
3. After the reaction is completed, the reaction mixture is usually neutralized with acid and base, and then extracted and washed with an appropriate solvent.
4. Finally, the pure product can be obtained by filtration, crystallization and drying.
Regarding safety information, 1-BOC-3-AMINOPIPERIDINE is generally relatively safe under reasonable operating conditions. However, it is still a chemical substance, so the following points need to be paid attention:
-During operation, avoid contact with skin and eyes. If exposed, immediately flush the affected area with plenty of water and seek medical help.
-When operating, maintain good ventilation conditions and avoid inhaling volatile gases or dust.
-In use and storage, should follow the correct laboratory safety procedures and personal protective measures.
Last Update：2024-04-09 21:01:54
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